This is a significant meta-study showing that antidepressants work for far more people than recent reports would suggest, often 20% better than a placebo, and for mild, moderate and severe depression. …
Despite recent debate about how well antidepressants really work in people with only mild or moderate depression, a new analysis of drug studies suggests they may have some benefit across the board.
Researchers found that more patients taking Prozac or Effexor had a substantial improvement in their symptoms than those taking a drug-free placebo pill, regardless of how severe those symptoms were to begin with.
The idea that unless you’re very, very ill, you’re not going to benefit from treatment does not appear to stand up” when looking closely, said the study’s lead author, Robert Gibbons, from the University of Chicago.